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Caloric restriction during weight loss can temporarily affect thyroid hormone levels , which may contribute to cold sensitivity without representing true hypothyroidism

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Another such example is Metformin , which is a medication for type 2 diabetes, which can also interfere with B12 absorption in the gut

*Correspondence: Su-Mei He, [email protected] Zhu, [email protected] Wei, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Clinical Nutrition, a section of the journal Frontiers in Nutrition Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers