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Dihexa: Aims for enduring circuit remodeling (learning/memory)
These changes were accompanied by a significant reduction in collagen deposition and overall fibrosis severity, suggesting that GLP-1 receptor agonism can modify established fibrogenic signalling cascades within the liver [38]
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Guo et al., 2024)
thus, we included this effect in a scenario analysis
For individuals with severe obesity (BMI 40 kg/m or 35 kg/m with significant comorbidities) who have not achieved adequate weight loss through non-surgical methods, bariatric surgery represents an evidence-based treatment option
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