In addition, professional treatment guidelines recommend the use of these medications in populations at high risk for developing major adverse cardiovascular events
Last reviewed: May 29, 2026
Pre-existing GI conditions If you have digestive issues like irritable bowel syndrome (IBS), small intestinal bacterial overgrowth (SIBO), gastroesophageal reflux disease (GERD), or other gut conditions, you may be more likely to experience stronger symptoms like sulfur burps
These effects occur in ~10% of patients, and can be mitigated by titrating your dose slowly per the drug instructions and your doctors guidance. Safety considerations Tirzepatide isn't appropriate for everyone, and certain medical conditions may require avoiding this medication entirely
Understanding how to manage nausea, vomiting, and appetite changes can make the difference between long-term success and discontinuation