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Metabolic Safety: IGF-1 and Glucose Effects One of the most clinically significant safety findings relates to AOD-9604s metabolic profile, particularly its lack of effects on insulin-like growth factor-1 (IGF-1) and glucose metabolism
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These are, however, as much about the reduced caloric intake as they are about the medication directly
Current research limitations include the absence of large-scale randomized clinical trials in humans, an still partial understanding of the precise molecular mechanisms, and a lack of detailed pharmacokinetic data in humans
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