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Well-designed clinical trials in humans are needed
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Researchers have extensively studied glutathione due to its involvement in antioxidant activity, mitochondrial function, cellular signaling, immune system regulation, and detoxification processes
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On one hand, pro-inflammatory immune cells (e.g., M1-type macrophages, Th17 cells) directly or indirectly contribute to cartilage degeneration and extracellular matrix degradation by releasing inflammatory factors (e.g., TNF-, IL-1, IL-6) and matrix-degrading enzymes (e.g., MMPs, ADAMTS)
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