At the end of the 72-week study, the mean percent (%) weight loss and average weight loss with tirzepatide (Zepbound) was: 15% for the 5 mg dose (about a 16 kg [35 lb] weight loss) 19.5% for the 10 mg dose (about a 20 kg [45 lb] weight loss) 20.9% for the 15 mg dose (about a 22 kg [48 lb] weight loss) 3.1% for placebo (about a 3 kg [7 lb] weight loss) The percentage of patients with a weight loss of 5% or more was 85% to 91% based on dose, compared to 35% with placebo
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The Bottom Line: Ozempic vs Mounjaro for Weight Loss Here is the clinical bottom line, clearly stated: Ozempic is not licensed for weight loss in the UK Wegovy is the correct licensed weight management product containing semaglutide Mounjaro produces approximately 22.5% average weight loss at maximum dose versus 14.920.7% for Wegovy a meaningful difference for patients seeking maximum results Wegovy has a formal NICE cardiovascular benefit label (April 2026) that Mounjaro does not yet have making it the preferred choice for patients with established CVD Wegovy is cheaper (99.99209.99 vs 139285 at Slinic) important for cost-sensitive patients Wegovy now has a pill option (MHRA June 2026) important for needle-phobic patients Mounjaro is the right choice for patients who want maximum weight loss and can afford it Neither Ozempic off-label nor any unregistered product should be your first choice when licensed alternatives are available from a GPhC-regulated UK pharmacy Side Effects: Ozempic vs Wegovy vs Mounjaro Since Ozempic and Wegovy contain the same drug, their side effect profiles are qualitatively identical the differences are quantitative (higher Wegovy doses produce more side effects than lower Ozempic doses)

Given these connections, it is crucial for patients on semaglutide to monitor their symptoms closely