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One small randomized controlled trial in 450 pregnant women in West Africa, without specified MTHFR genotype but at high risk for preeclampsia, found that supplementation with 15 mg of riboflavin daily was not effective in preventing the condition (29), but the study was likely underpowered to detect a significant effect
For ipamorelin, it referenced a study reporting serious adverse events, including death, when the peptide was given intravenously
Sources: Prkacin et al., 2001 | Sikiric et al., 1993 Stomach Lining Protection: Chronic Cytoprotection A second Prkacin et al
Together, they address multiple aspects of the healing cascade
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