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What they found: Cagrilintide 4.5 mg: 10.8 % weight reduction vs 3.0 % placebo (p 40 % of patients achieved 25 % weight reduction , historically unprecedented Safety profile in line with Phase 2 data Why it matters: REDEFINE 1 confirmed CagriSema as the largest body-weight signal reported in the published incretin literature to date
In: Blood-Brain Barrier
Coverage of GLP-1s for weight loss Coverage for specific GLP-1s Breadth of GLP-1s covered Ro has been invaluable
Hence, by addressing these methodological limitations, such as adequacy of follow-up, generalizability, outcome measures, and small sample sizes, future research can provide more robust evidence of the potential benefits and risks of GLP-1 RAs in psychiatric disorders
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