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The FDA and a local institutional review board (IRB)comprising scientists and healthcare professionals from different institutions and hospitals involved in clinical researchreview the application

10.1103/PhysRevE.77.021201 110 JiangY.GaoH

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This persistent challenge likely reflects multiple factors including prior metabolic adaptations, changes in body composition, lifestyle factors, and possibly residual metabolic effects not fully corrected by thyroid hormone replacement alone