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Because the milligram amount is fixed, a lighter body gets more drug exposure per pound: roughly 22% more at 70 kg and about a third less at 120 kg, compared with a 90 kg reference. The dose still comes from response and tolerability, but a lighter person is running a hotter exposure at the same number on the vial

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However, the observation that caffeine reduces the stimulation in-vivo (AcbSh DA, by reverse dialysis) and in-vitro (pVTA DA neuronal firing) by exogenous salsolinol, as well as the stimulation of pVTA DA neuronal firing in-vitro by morphine, confirms that salsolinol generation-independent mechanisms should be envisioned