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He states that there are a range of unpleasant side effects, and that is not needed if a person is already taking estrogen and/or testosterone via hormone replacement therapy (HRT)

Up-regulation of EGR-1 and cyclin D1 A bit more technical: EGR-1 (Early Growth Response 1) and cyclin D1 are transcription factors, proteins that, in the cells nucleus, determine which genes are switched on

Brain Res 1316:3542

doi:10.1001/jamaophthalmol.2025.0349 9

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