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studies have shown a 0.6% A1C decrease after approximately 6 months of sitagliptin or alogliptin therapy, compared with 0.5% for saxagliptin and 0.4% for linagliptin
Moreover, its expression appears to be influenced by metabolic stress, with it being increased in islets from diet-induced obese mice compared to normal weight animals (104), but lower in human islets from diabetic compared to non-diabetic donors (98, 99, 104)
In fact, these therapies often complement each other well, as both decline with age
These pathways regulate not only appetite but also dopamine and serotonin signaling, neurotransmitters directly involved in mood control
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