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Lonardo A, Nascimbeni F, Mantovani A, Targher G
The results by maintenance dose were as follows: 5mg/week Maintenance Dose: Resulted in an average weight loss of 16.0% with over 85% of participants losing more than 5% of their body weight and 32% losing over 20% 10mg/week Maintenance Dose: Resulted in an average weight loss of 21.4% with over 89% of participants losing more than 5% of their body weight and 50% losing over 20% 1 5mg/week Maintenance Dose: Resulted in an average weight loss of 22.5% with over 91% of participants losing more than 5% of their body weight and 57% losing over 20% Placebo: Resulted in an average weight loss of 2.4% with 35% of participants losing more than 5% of their body weight and only 3% losing over 20% Source: Jastreboff et al., SURMOUNT-1, NEJM 2022
To induce acute liver injury, 8-week-old NSI mice received two consecutive intraperitoneal injections of DMN (7 mg/kg, Sigma, 1.0% dissolved in saline)
Oral semaglutide is typically used at doses of 7 mg or 14 mg daily, which correspond to relatively low GLP-1 receptor activation compared to injectable doses
It gave the field the confirmation that we were on the right track, said Holst
