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The conversion of homocysteine to methionine reduces the potential for damage because the reaction results in the formation of the super-antioxidant glutathione
But even then, the injection site makes a difference
Rarely, involuntary movements and seizures are the initial symptoms of deficiency
This is why B12 is included in compounded formulations
Typical shot schedules use a short loading phase (26 weeks) followed by monthly to every 23 months maintenance (AAFP
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