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Close to TBM, follicular dendritic cells (FDC) are localised in GC, which attach antigen material to their surface and, in contrast to bone marrow-derived DC, neither take it up nor present it via MHC molecules
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However, as with all other types of drugs, these medicines are not free from possible side effects
Moreover, these HLCs displayed significant CYP450 metabolic activities for CYP3A4, CYP2C9, and CYP2D6, similar to PHs
The above-reported evidence suggests that, on the basis of the initial localization of pathological forms of -syn, different subtypes of PD can be identified in addition to the traditional staging framework based on the canonical Braak pattern, which is characterized by the caudo-rostral spread of -syn-positive LBs, which originate in the brainstem and systematically ascends toward the neocortex [101, 102]
