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Some patients experience dose tolerancewhere their initial maintenance dose becomes less effective after 612 months of consistent use
Front Physiol 13:983961 Giugliano D, Scappaticcio L, Longo M, Caruso P, Maiorino MI, Bellastella G, Ceriello A, Chiodini P, Esposito K (2021) GLP-1 receptor agonists and cardiorenal outcomes in type 2 diabetes: an updated meta-analysis of eight CVOTs
This antioxidant effect also stabilizes mitochondrial membranes, preventing the release of apoptogenic factors in -cells and other insulin-sensitive tissues (Papuc 2022)
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