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In addition, the Wilmott laboratory has defined an EOMES + CD69 + CD45RO + effector memory T-cell phenotype within tumors that is more abundant in responders to the combination of anti-PD-1 therapy and anti-CTLA-4 therapy than in nonresponders [251]
However, next-generation oral drugs in trials are designed to offer results comparable to injections
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The revised labeling added explicit language about the risk of intracranial meningioma, advised monitoring patients for signs of brain tumors, and recommended discontinuing use of the drug if meningioma development or growth is detected
The same approach was followed for each secondary outcomecardiovascular death, nonfatal myocardial infarction, and nonfatal strokeusing the corresponding event rates and hazard ratios from the SOUL trial
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