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Ferroptosis enhanced diabetic renal tubular injury via HIF-1/HO-1 pathway in db/db mice

Clinical studies show that the combination therapy of semaglutide and metformin is more effective than using each medication alone

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Potential risks include growth hormone's counter-regulatory effects on glucose metabolism that may oppose tirzepatide's benefits, additive gastrointestinal symptoms, and growth hormone-related adverse effects such as edema and joint pain

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