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There is every reason to argue that the efficacy observed for compounds 1 and 2 in vivo incorporates a similar role for the host immune response as seen for other schistosomicidal agents
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[11] [12] Other key factors include: Dose level : Higher doses (e.g., 12 mg in trial protocols) produced greater weight loss than lower doses, though they were also associated with a higher incidence of gastrointestinal side effects
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