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The dosage escalation followed a specific titration schedule starting at lower doses and building upward every four weeks

"Patients finally have an obesity treatment available to them that actually works -- but because of ongoing challenges with supply -- they have to literally hunt down their medication, sometimes calling every pharmacy in their city just to come up empty," he wrote

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This is a significant step up in commitment, complexity, and cost, but it also represents a significant step up in effectiveness

The four-week intervals Each dose is held for four weeks before the next increase