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ABCB1 (MDR1) and ABCG2 (BCRP), both members of the ATP-binding cassette (ABC) transporter family, play a pivotal role in facilitating the diffusion of TMAO

All FDA-approved GLP-1 medications are administered via subcutaneous injection or oral tablets, requiring prescription from licensed healthcare providers

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Life Sci (2021) 270:118966

Lower doses might provide immunomodulatory benefits while minimizing these troublesome symptoms, potentially improving treatment adherence