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Patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2 should not use this medication

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The enzymatic reaction was initiated by adding 1 mL of GPx enzyme solution (3000 units/liter) to 9 mL of a mixture containing potential interfering substances

It has also been suggested that DPP-4 might be secreted into the interstitial spaces within the islets (100) and, accordingly, DPP-4 activity can be measured in the media of human islet incubations (101), but whether this is simple shedding of membrane-associated DPP-4 or regulated secretion is not known

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