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Pogacnik et al

In biochemical systems, actin-binding peptides derived from thymosin beta-4 function as regulators of cytoskeletal assembly by influencing the equilibrium between monomeric and filamentous actin

Disruptions in this process may result in reduced in C2 levels

In vivo, Ex-4 has been demonstrated to inhibit prostate cancer cell growth by activating GLP-1R, reducing s-phase kinase-associated protein-2 (SKP2) gene expression, subsequently increasing p27Kip1 (p27) protein levels, and inducing tumor cell cycle arrest [67]

(PubMed) Ye Y, Li J, Yuan Z

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