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The rationale for triple agonism is based on preclinical research demonstrating that glucagon receptor activation contributes to energy expenditure and lipid metabolism through distinct mechanisms from those engaged by GLP-1R and GIPR agonism
This beneficial effect appears to be primarily indirect, resulting from weight loss and improved metabolic parameters rather than direct hepatic action
Science 390:eadp5056
Upper respiratory tract infections: This can include symptoms like a runny or stuffy nose, sore throat, and cough Diarrhea Serious Side Effects : Stop taking Tradjenta and seek immediate medical attention if you experience any of the following: Pancreatitis: This is a serious inflammation of the pancreas
Wegovy and Saxenda, two weight loss drugs made by Novo Nordisk, are not included in their PAP
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