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TMAO exists in human blood circulation and cerebrospinal fluid (CSF) 110112 and serves as a critical mediator in the gut-brain axis
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[209] [204] [195] Amphetamine's effect on intracellular calcium is associated with DAT phosphorylation through Ca 2+ /calmodulin-dependent protein kinase II alpha (CAMKII), in turn producing dopamine efflux
The result is then eliminated through the usual pathway
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