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FOXO4-DRI has three main pharmacogenetic advantages: its stability (resistance to degradation by cellular proteases), half-life (compared to L-peptide equivalents, it's longer), and cell-penetrating properties (cell-penetrating sequences improve intracellular delivery)

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But those are different trials with different durations and doses, and cagrilintides strongest data are as the CagriSema combination, so any ranking is a cross-trial inference rather than a proven result

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