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Immature DCs express high levels of TLR4, which triggers a cascade of responses in the TLR4 pathway when DCs are stimulated by antigens, leading to DCs expressing high levels of chemokine receptors, maturing during migration and initiating an adaptive immune response (86, 87)

Small extracellular vesicles from human adipose-derived stem cells attenuate cartilage degeneration

Scenario Analysis 11.2.1.1

Weight loss drives much of the benefit, but the drugs also appear to act directly on liver inflammation

(1) The inflammatory response: COX-2 is upregulated in response to inflammation and its expression level is significantly increased in patients with ACM