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Using Affymetrix microarray analysis on human fibroblast cultures, researchers documented that GHK-Cu at physiologically relevant concentrations (1-10 nM) significantly altered expression of 4,000+ genesapproximately 31.2% of all genes represented on the array

However, these trials were never published in detail in peer-reviewed journals

PMID 329728

In the SURMOUNT-1 obesity trial, tirzepatide produced mean weight reductions of roughly 1521% depending on dose over 72 weeks ( Jastreboff et al., NEJM 2022

"And it's not because of any magic it's because these are natural substances that our bodies make and are familiar with, so that's what gives them this incredible safety profile." The FDA, however, has publicly stated that there is not enough evidence from human clinical trials on the safety or efficacy of these drugs