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IGF-1 LR3 is more potent than regular IGF-1 because of the decreased binding of Long R3 IGF-1 to IGF binding proteins, allowing it to remain active up to 120 times longer compared to native IGF-1
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The Brain Hepatocyte Growth Factor/c-Met Receptor System: A New Target for the Treatment of Alzheimer's Disease Wright JW, Harding JW Journal of Alzheimer's Disease (2015) This review article from the Washington State University research group analyzed the hepatocyte growth factor (HGF) and c-Met receptor signaling pathway as a therapeutic target for Alzheimer's disease
Community resources describe pulling the vial out, drawing the dose, and returning it immediately
Severe nausea requiring treatment discontinuation was rare in monotherapy trials, with only about 1% of participants in the REDEFINE 1 trial stopping treatment because of adverse events overall
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