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These investigations help clarify the structural determinants of receptor activation and desensitization, supporting the rational design of next-generation peptide analogs with improved pharmacodynamic profiles
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Spectra were background-corrected by subtraction of the spectrum obtained in the presence of microsomes and NADPH, respectively intact HepG, but in absence of NFT
Alteration of membrane cholesterol content plays a key role in regulation of cystic fibrosis transmembrane conductance regulator channel activity
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