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These cardiovascular characterisation studies established that MT-IIs haemodynamic effects are mechanistically related to its central MC3R/MC4R activation rather than to peripheral melanocortin receptor engagement
Moreover, ROS-related hypoxia genes also exhibited differing expression patterns in this dataset (Supplementary Fig
K.GrsoyM.LoimarantaV.RautavaJ
This characteristic suggests the peptide works through regulatory mechanisms that plateau rather than dose-dependent stimulation that could run out of control
Neznanov N, Gorbachev AV, Neznanova L, et al
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