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However, He argued that because the chief clinical symptom of SCD is vaso-occlusive pain due to sickling, the decreased oxygen release may be tolerated

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PLOS ONE 7(10): e47559

the studies looking more specifically at mechanistic pathways of action will typically be focused on micro-analysis, whereas those looking at the level of tissue healing on a macro-scale will be focused on biomechanical and functional measures

Researchers are expected to follow institutional biosafety rules, animal-care guidelines, and local regulations when working with KLOW, just as they would with any other unapproved laboratory reagent