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Additionally, around 12% of oxygen used in mitochondrial metabolism produces free radicals, which can lead to oxidative stress and even DNA damage [2]

Retatrutide, a GIP, GLP-1, and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial

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These hormonal fluctuations can also disrupt sleep, which can mess with your metabolism as well

Trial subjects reported improved skin hydration within 1-2 weeks, noticeable texture and firmness improvements at 4-8 weeks, and reduced fine lines with better skin resilience at 8-12+ weeks