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This tightly regulated process begins with signal detection by microglia through pattern recognition receptors (PRRs), such as toll-like receptors (TLRs), or other damage associated receptors, such as receptor for advanced glycation end products (RAGE) and scavenger receptors, prompting a transition from a surveillant to a reactive state ( (IL-1), and IL-6), chemokines, and ROS to neutralize pathogens and increase cell recruitment to the site of inflammation
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Use new sterile equipment for each preparation or administration and use a suitable sharps container [17]
E.RabinowitzJ
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