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In Mecp2-deficient mice, NTS neurons show significantly reduced amplitudes and frequencies of sIPSCs and mIPSCs, indicating impaired synaptic transmission, and decreased eIPSC amplitudes, though the paired-pulse ratio (PPR) remains unchanged, suggesting that postsynaptic mechanisms may contribute to the weakening of GABAergic inhibition
doi:10.1001/jamainternmed.2024.2525 36
Put simply, it influences hormonal signaling in your brain to reduce appetite, help you feel full longer after a meal, and can even slow the rate at which your stomach digests and processes food
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However, the molecular mechanisms through which ferroptosis regulates the onset and progression of AD remain poorly understood
