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In subgroup analyses based on the drugs used in the control arms, the overall cancer risks were identical in the tirzepatide group compared to the placebo, insulin, and GLP-1RA groups
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These changes enhance the activity of the renin-angiotensin system (RAAS), contributing to vasoconstriction, sodium retention, and heightened blood pressure, thereby exacerbating the risk of hypertension [460]
However, he added that health care professionals should consider potential adverse events and weigh them against the drugs benefits
Glucose-dependent insulinotropic polypeptide (GIP): Works synergistically with GLP-1 to enhance insulin release and may also play a role in fat metabolism
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