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Users report generally milder systemic side effects than injectable tirzepatide (likely due to lower absorption) but may experience oral-specific side effects including taste disturbances, tongue irritation, and dry mouth
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By pointing to reaction-related impurities, it's giving regulators and consumers a concrete safety issue to consider
The current findings have subsequently been supported by results from the phase II dose-finding trial with oral semaglutide in subjects with T2D [10]
In conclusion, both SGLT2-i and GLP1-RA seem to have several effects on RAAS, though additional studies are needed to clarify this relationship
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