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Beyond weight management, some GLP-1 medications have shown additional health effects in clinical research
The National Institute for Health and Care Excellence (NICE) recommends specific GLP-1 receptor agonists in defined circumstances for type 2 diabetes when metformin and other treatments are insufficient, and for weight management through specialist services for people meeting specific criteria
That said, many find that GLP-1 fatigue lingers and interferes with quality of life
![Tirzepatide vs. Semaglutide: Which GLP-1 Better Preserves Muscle? [SURMOUNT-5 Data]](https://www.clinicalnutritioncenter.com/wp-content/uploads/2026/04/research-image-2026-04-10-1024x559.jpg)
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