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TB-500 suppresses pro-inflammatory cytokines (TNF-, IL-1) while increasing anti-inflammatory mediators like IL-10, leading to decreased immune-mediated tissue damage

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Flow cytometric analysis revealed that although intranasal IL-33 induced robust eosinophilia in both lung and BALF, melatonin significantly limited this increase ( Figures 2G, H ), even under melatonin receptor antagonism ( Figures 2G, H )

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