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doi: 10.1016/S2213-8587(23)00356-X 81 ApovianCMMcDonnellME

MS, medial septal nucleus

IGF-1 signalling has been linked to neurotrophic and neuroprotective processes , and IGF-1 LR3 provides a consistent model for exploring these effects

the mechanistic rationale (BPC-157 favouring fibroblast and NO-mediated repair, T4 favouring actin dynamics, cell migration and angiogenesis) is entirely extrapolated from separate animal experiments

The lipid tail allows retatrutide to bind serum albumin, which slows clearance and gives the peptide a half-life long enough for once-weekly dosing in published animal pharmacokinetic work