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Impact on Body Weight: Semaglutide has been extensively studied for its role in weight management

Over the 5-year follow-up, there was an all-cause increased mortality risk of 1.29-fold vs the normokalemia cohort (45% vs 37%), a 1.40-fold increased risk for major adverse cardiac events (MACEs) (60% vs 45%), a risk of 1.72 (34% vs 19%) for RAASi discontinuation, and a 1.94-fold higher risk of hospitalization with arrhythmia compared with the matched normokalemia cohort [20]

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Immunocompromised patients, premature infants, critically ill individuals, those with central venous catheters, and patients with severe acute pancreatitis should avoid GLP-1 probiotics due to elevated risk of serious infections and adverse outcomes

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