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This markedly increased its half-life in the body, making it more suitable for clinical use than human GLP-1
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What they lacked was glycine
A structure-based assignment of the glutathione activator site without transition-state analogues is much more difficult because of labile GSH interactions 2 that likely depend not only on the presence of the first glutathione moiety but also on conformational changes of the glutathionylated enzyme 3,12,37,44
This protective effect is particularly important for people with obesity, who often face higher cardiovascular risks
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