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Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib

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59 SMOKING AS A RISK FACTOR FOR CATARACT Smoking and tobacco chewing appear to induce oxidative stress and have been associated with both diminished levels of antioxidants, ascorbate, and carotenoids 60 , 61 , 62 , 63 , 64 , 65 and with enhanced cataract at a younger age