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Presented for research literature review only Aoun B et al
Oxidative stress and the etiology of insulin resistance and type 2 diabetes
Official announcement here: The approval of the oral Wegovy pill doesnt just boost convenience - it fundamentally expands the addressable obesity market by converting a therapy from a niche specialty product (injections) into a mainstream, mass-market chronic medicine, similar to how statins or antihypertensives are prescribed
In addition, the activation of GLP-1R results in a cascade that activates adenyl cyclase via G s , resulting in an increased secretion of cyclic adenosine monophosphate (cAMP) secretion and activating cAMP-dependent protein kinase (PKA)
10.1210/en.2007-1743 44 HenningfieldJ
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