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Tesamorelin is an FDA-approved treatment for reducing excess abdominal fat in HIV-infected patients with lipodystrophy and may be administered as a standalone treatment

Another cAMP effector, exchange protein directly activated by cAMP (Epac), contributes to the regulation of angiogenesis by inhibiting -secretase, an enzyme required for the intracellular cleavage Notch and thereby activation of the Notch pathway

There was also a dose-dependent effect on BW gain, but no effect on total IGF-I levels, IGFBPs, or serum markers of bone formation and resorption

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Yamazaki N, Yamanaka Y, Hashimoto Y, Shinohara Y, Shima A, Terada H: Structural features of the gene encoding human muscle type carnitine palmitoyltransferase I