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The barrier proteins that should seal moisture in and keep irritants out, like filaggrin and loricrin, get downregulated
PMCID: PMC9037278
In light of emerging clinical scenarios such as adverse effects, patient preference, cost pressures or formulary decisions some healthcare professionals may consider switching a patient from tirzepatide to semaglutide
others notice non-scale wins first (steadier appetite, easier portion control, fewer cravings) and see weight changes later as dosing and habits settle
Semaglutide significantly reduced blood glucose concentrations in glucose tolerance tests
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