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This matters because a proposed mechanism is not the same as a proven clinical benefit
This is inherent to the mechanism and does not diminish with continued use
& Hulce, M
2 Fernandez-Checa J, Lu SC, Ookhtens M, DeLeve L, Runnegar M, Yoshida H, Saiki H, Kannan R, Garcia-Ruiz C, Kuhlenkamp JF, Kaplowitz N: The regulation of hepatic glutathione
These effects are typically mild and often resolve with dose adjustment
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