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Clinical trials tell the story clearly: Semaglutide (Wegovy) produces average weight loss of 15 to 16 percent of body weight over 68 weeks Tirzepatide (Zepbound) produces average weight loss of 20 to 22.5 percent of body weight, with some participants losing even more Retatrutide , a triple receptor agonist still in clinical trials, has shown weight loss approaching 24 percent in some study arms Tranont Activate, based on the Metabolaid studies of its key ingredients, is associated with roughly 3 extra pounds of weight loss over 8 weeks compared to placebo

If symptoms ever escalate beyond what oral glucose can manage, treat it as a medical emergency

Due to recent supply constraints affecting some formulations, NHS England has issued guidance prioritising continuation of therapy for existing patients with type 2 diabetes

Patients should report any suspected side effects via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk or via the Yellow Card app)

BMC Cancer 18 , 657 (2018)