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In addition to biocompatibility, biodegradation, bioadhesiveness, and biofunctionality of the NDBs, several drawbacks must be addressed, such as low stability, low melting point, high surface tension, structural complexity, and well-known immunological response from organisms (Ige et al., 2012

Specific binding studies indicate that silent agonists stabilize certain receptor conformations favorable for interaction with endogenous neurotransmitters, potentially leading to more nuanced control of receptor activity [79, 80]

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But the pharmacist said that the reason is that it could get contaminated