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Diabetes (2017) 66(5):133445
Chicago Oisin, Anthoni
Besides the results from preclinical models of breast cancer shows that blocking the cancer's ability to use glutathione slowed down tumor growth Further making use of an advanced technology to search for therapies that could inhibit a tumor's ability to use glutathione, the team identified pharmacological targeting of the activity of -glutamyltransferases (GGT) using GGsTop, a putative inhibitor of GGT activity prevents the breakdown of circulating GSH leading to reduced tumour cysteine levels and slowed tumour growth In a nutshell, the findings indicate a non-canonical role for GSH in supporting tumours by acting as a reservoir of amino acids and that depriving tumours of extracellular GSH or inhibiting its breakdown could potentially prove to be a therapeutically tractable approach for patients with cancer Hecht, F., Zocchi, M., Tuttle, E.T
For patients with to-moderate obesity and high cholesterol medical weight management programs combining physician oversight, nutrition coaching and GLP-1 medications like semaglutide can produce 15-20% body weight loss
Nausea, vomiting, diarrhea, and constipation remain the most common issues
